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pentobarbital will decrease the extent or effect of gefitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or effect of meloxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.
pentobarbital will lower the extent or impact of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
pentobarbital will decrease the extent or impact of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with potent CYP3A4 inducers may result in diminished serum concentrations and loss of antimalarial efficacy
benzhydrocodone/acetaminophen and pentobarbital the two enhance sedation. Steer clear of or Use Alternate Drug. Limit use to sufferers for whom alternate treatment method alternatives are insufficient
Pursuing oral or parenteral administration, barbiturates commonly cross the placental barrier and are distributed throughout fetal tissues with highest concentrations found in the placenta, fetal liver, and brain; fetal blood degrees strategy maternal blood concentrations following parenteral administration
Soon after stopping a CYP3A4 inducer, because the effects with the inducer decline, the fentanyl plasma concentration will maximize which could increase or lengthen both equally the therapeutic and adverse effects.
pentobarbital will minimize the extent or influence of tolterodine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lessen the level or result of zolpidem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
pentobarbital will minimize the level or influence of diclofenac by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Unidentified.
Contraindicated. Coadministration of lorlatinib with potent CYP3A inducers is contraindicated. Discontinue the potent CYP3A inducer for 3 plasma 50 %-lives ahead of initiating lorlatinib.
Drugs that involve prior authorization. This restriction needs that unique clinical requirements be fulfilled prior to the acceptance in the prescription.
pentobarbital will lessen the extent or result of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.
pentobarbital will decrease the extent or outcome of pimavanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Prevent coadministration if more info at all possible. Watch for reduced pimavanserin efficacy. A rise in pimavanserin dosage might be essential.